Perioperative chemotherapy has a role to play in the management of patients with resectable liver metastases from colorectal cancer Chemotherapy given both before and after surgery to remove liver metastases (secondary cancers) improves progression free survival over surgery alone in patients with metastatic colorectal cancer, concludes a study published recently in The Lancet. The phase III European Organization for Research and Treatment of Cancer (EORTC) study demonstrated that perioperative chemotherapy (i.e. that given before and after surgery) was compatible with major liver surgery.